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. Author manuscript; available in PMC: 2011 Sep 15.
Published in final edited form as: Bioconjug Chem. 2010 Sep 15;21(9):1691–1702. doi: 10.1021/bc100292x

Figure 6.

Figure 6

Effect of trimeric ribonuclease conjugates on tumor volume and body weight (insets) of Balb c(−/−) mice in xenograft models bearing human A549 lung tumors. Data points are the mean (± SE) for n mice; % TGI values in parentheses were calculated with eq 5. Vehicle control (○; n = 7). (A) (G88C RNase A)3–8 (▲, 25 mg/kg; i.p., 1×wk, n = 7) and cisplatin (□, 6 mg/kg; i.p., 1×wk, n = 7). (B) Photographs of representative mice treated with vehicle (left) or (G88C RNase A)3–8 (right) on day 70 of the experiment in panel A. (C) (G89C RNase 1)3–8 (▼, 7.5 mg/kg; ▲, 75 mg/kg; i.p., 1×wk, n = 7) and erlotinib (□, 100 mg/kg; p.o., 2×wk, n = 7).