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EDEMA causes significant increases in STAT-3 and NF-kappa B nuclear activation as well as in the levels of phosphorylated STAT-3. An n of 5–7 was used for all CONTROL groups and an n of 7–8 was used for all EDEMA groups. (* represents statistical difference (p<0.05) between CONTROL and EDEMA groups; (a) STAT-3 nuclear activation, (b) phosphorylated STAT-3, (c) NF-kappa B nuclear activation)
