Table II.
Short-term outcomes
| Characteristic* | Group (n, %) | ||||
|---|---|---|---|---|---|
| Seizures (N=414) |
No Seizures (N=6085) |
||||
| In-hospital | |||||
| Surfactant administered# | 373 (90) | 4873 (79) | |||
| Prophylactic indomethacin# | 127 (31) | 2305 (38) | |||
| Treatment indomethacin# | 216 (52) | 2249 (37) | |||
| PDA# | 270 (65) | 2752 (45) | |||
| BPD# | 300 (72) | 2818 (46) | |||
| Postnatal steroids# | 170 (41) | 1176 (19) | |||
| Early-onset sepsis | 13 (3) | 93 (2) | |||
| Late-onset sepsis# | 253 (61) | 2226 (37) | |||
| Surgery (PDA/NEC/ROP) # | 198 (48) | 1364 (22) | |||
| Meningitis# | 62 (15) | 167 (3) | |||
| IVH, grade III or IV# | 163 (39) | 573 (10) | |||
| Cystic PVL# | 65 (16) | 221 (4) | |||
| Ventriculomegaly#,† | 168 (43) | 652 (14) | |||
| Shunt for PHH# | 59 (14) | 97 (2) | |||
| ROP ≥ stage 3# | 163 (39) | 1185 (19) | |||
| At discharge ‡ | |||||
| Hearing screen failed# | 36/271 (13) | 291/3973 (7) | |||
| Anticonvulsant therapy# | 18/272 (7) | 8/4006 (<1) | |||
*
Missing data (total number of subjects): surfactant (20), prophylactic indomethacin (3), treatment indomethacin (27), PDA (1), BPD (8), postnatal steroids (8), late-onset sepsis (4), meningitis (1), IVH grade III or IV (52), cystic PVL (30), shunt for PHH (7), hearing screen failed (35), anticonvulsant therapy (1).
#
P < 0.01 using χ2 test.
†
Ultrasound at 36 weeks not routinely performed by all centers. Seizure group has missing data for 20 subjects; control group has missing data for 1370 subjects.
‡
Hearing screen and discharge medications were not queried before 2/14/2002; data represent subjects enrolled into database after this date and data are represented as n/N (%).