Table 3.

Patients without and with reduced GFR across ENNP1 genotype groups

							Genetic model
							Additive	Recessive	Dominant
Panel A – Gargano sample	KK		KQ		QQ		OR	OR	OR
	n	%	n	%	n	%	(95%C.I.)	(95%C.I.)	(95%C.I.)
Reduced GFR − n	408	72	137	24	22	4	1.33 (1.0–1.9) P=0.1 1.43 (1.0–2.1)^ P=0.07	0.88 (0.30–2.6) P=0.8 0.83 (0.2–2.8)^ P=0.8	1.55 (1.0–2.3) P=0.04 1.69 (1.1–2.6)^ P=0.02
Reduced GFR + n	73	62	40	34	4	4
Panel B – Boston sample	KK		KQ		QQ		OR	OR	OR
	n	%	n	%	n	%	(95%C.I.)	(95%C.I.)	(95%C.I.)
Reduced GFR − n	291	72	99	25	11	3	1.32 (0.9–1.8) P=0.1 1.39 (1.0–2.0)^ P=0.08	0.80 (0-3-2.5) P=0.8 1.04 (0.3–3.9)^ P=0.9	1.47 (1.0–2.1) P=0.04 1.50 (1.0–2.2)^ P=0.05
Reduced GFR + n	117	64	61	34	4	2
Panel C – Padua sample	KK		KQ		QQ		OR	OR	OR
	n	%	n	%	n	%	(95%C.I.)	(95%C.I.)	(95%C.I.)
Reduced GFR − n	70	73	24	25	2	2	1.72 (0.8–3.7) P=0.2 1.66 (0.7–3.8)^ P=0.2	1.68 (0.2–19.2) P=0.7 3.4 (0.3–45)^ P=0.4	1.90 (0.80–4.5) P=0.1 1.77 (0.7–4.5)^ P=0.2
Reduced GFR + n	17	59	11	38	1	3
Panel D – All samples	KK		KQ		QQ		OR	OR	OR
	n	%	n	%	n	%	(95%C.I.)	(95%C.I.)	(95%C.I.)
Reduced GFR − n	769	72	260	25	35	3	1.34 (1.1–1.7) P=0.01 1.41 (1.1–1.8)^^ P=0.006	0.83 (0.4–1.7) P=0.622 0.98 (0.4–2.2)^^ P=0.9	1.52 (1.2–2.0) P=0.002 1.58 (1.2–2.1)^^ P=0.002
Reduced GFR + n	207	63	112	34	9	3

KK: patients carrying the K121/K121 genotype; KQ: patients carrying the K121/Q121 genotype; QQ: patients carrying the Q121/Q121 genotype;

GFR: glomerular filtration rate (GFR conversion factor for SI unit is 0.01667)

Reduced GFR − = patients with GFR ≥ 60 ml/min/1.73m²

Reduced GFR + = patients with GFR < 60 ml/min/1.73m²

OR (95% C.I.): odds ratio (95% confidence interval);

^{^}adjusted for age, sex, duration of diabetes, HbA1c, hypertension, BMI;

^{^^}adjusted also for place