Table 3.

PIVKA-II versus AFP in differentiation of patients with HCC from cirrhosis

Variables	TP	FP	TN	FN	Sensitivity [%(95% CI)]	Specificity [%(95% CI)]	PPV (%)	NPV (%)	Diagnostic accuracy (%)
PIVKA-II	56	14	35	3	80.0 (0.68–0.88)	92.1 (0.77–0.97)	94.9	71.4	84.2
AFP	51	19	25	13	72.8 (0.60–0.82)	65.8 (0.48–0.79)	79.7	56.8	70.4
AFP/PIVKA-II	64	6	24	14	91.4 (0.81–0.96)	63.1 (0.45–0.77)	82.0	63.1	81.1
PIVKA-II + AFP	47	23	36	2	67.1 (0.54–0.77)	94.7 (0.80–0.99)	95.9	61.0	76.8

TP true positive, FP false positive, TN true negative, FN false negative, PPV positive predictive value, NPV negative predictive value