Table 3.
Characteristics of the studied patients with non-cholestatic CLD by 25-hydroxy vitamin D status (n = 90)
| Variables | Vitamin D (nmol/l) | |||
|---|---|---|---|---|
| <25 | 25–49 | 50–79 | ≥80 | |
| n (%) | 23 (25.6) | 23 (25.6) | 15 (16.7) | 29 (32.2) |
| Vitamin D (n mol/l)* | 17.67 ± 3.48 | 38.09 ± 7.76 | 64.75 ± 10.27 | 103.78 ± 16.90 |
| PTH (pmol/dl) | 18.97 ± 9.81 | 21.04 ± 9.18 | 24.70 ± 14.99 | 25.41 ± 16.28 |
| Ca (mg/dl) | 8.99 ± 0.39 | 8.95 ± 0.77 | 8.85 ± 0.57 | 8.94 ± 0.52 |
| P (mg/dl) | 2.98 ± 0.61 | 3.08 ± 0.58 | 3.15 ± 0.65 | 3.13 ± 0.55 |
| Cirrhotic patients, n (%)* | 23 (45.1) | 16 (31.4) | 5 (9.8) | 7 (13.6) |
| Child–Pugh classification (n, %)a,* | ||||
| Child A | 5 (22.7) | 5 (22.7) | 5 (22.7) | 7 (31.8) |
| Child B | 6 (60.0) | 4 (40.0) | 0 (0) | 0 (0) |
| Child C | 12 (63.2) | 7 (36.8) | 0 (0) | 0 (0) |
| MELD scorea,* | 17.70 ± 5.57 | 13.62 ± 3.34 | 10.71 ± 2.77 | 10.20 ± 2.43 |
| Albumin (g/dl)* | 2.87 ± 0.47 | 3.43 ± 0.75 | 4.13 ± 0.78 | 4.21 ± 0.48 |
| INR* | 1.72 ± 0.47 | 1.39 ± 0.27 | 1.13 ± 0.12 | 1.15 ± 0.18 |
| PLT count* | 74,130 ± 32,169 | 137,652 ± 94,800 | 164,400 ± 63,359 | 188,551 ± 79,999 |
| Hb (g/l)* | 10.04 ± 1.88 | 11.87 ± 2.83 | 13.32 ± 2.17 | 13.80 ± 1.62 |
| Bil (mg/dl)* | 4.40 ± 4.01 | 1.89 ± 1.06 | 1.46 ± 0.82 | 1.26 ± 1.01 |
| AST (U/l) | 89.39 ± 60.00 | 89.43 ± 75.24 | 76.14 ± 45.11 | 64.13 ± 61.03 |
| ALT (U/l) | 55.83 ± 34.44 | 69.26 ± 59.81 | 77.87 ± 49.04 | 84.17 ± 73.35 |
| ALP (U/l) | 269.83 ± 89.22 | 278.78 ± 133.75 | 246.87 ± 89.97 | 269.24 ± 112.77 |
| Cr (mg/dl) | 0.96 ± 0.21 | 0.95 ± 0.18 | 0.93 ± 0.12 | 0.97 ± 0.17 |
| Urea (mg/dl) | 35.17 ± 9.60 | 29.83 ± 6.97 | 29.80 ± 6.71 | 31.28 ± 7.94 |
Data are expressed as mean ± SD, unless otherwise is stated
CLD chronic liver disease, MELD Model for End-Stage Liver Disease, PTH parathyroid hormone, Ca calcium, P phosphate, INR international normalized ratio, PLT platelet count, Hb hemoglobin, Bil bilirubin, AST aspartate transaminases, ALT alanine transaminases, ALP alkaline phosphatase, Cr creatinine
aCalculated in cirrhotic patients only
* P < 0.001; P values are derived from chi square analysis or analysis of variances (ANOVA) among the four groups