Skip to main content
. Author manuscript; available in PMC: 2010 Sep 16.
Published in final edited form as: Diabetes. 1997 Jun;46(6):1087–1093. doi: 10.2337/diab.46.6.1087

TABLE 1.

Effects of leptin on 1-h insulin and somatostatin release from islets isolated from 10-week-old female ob/ob mice

Treatment Insulin (ng/ml) Somatostatin (pg/ml)
5.5 mmol/1 glucose 7.58 ± 0.74 40.42 ± 2.52
5.5 mmol/1 glucose
100.0 ng/ml leptin
5.47 ± 0.68* 40.91 ± 5.77
11.0 mmol/1 glucose 8.63 ± 0.48 45.31 + 4.50
11.0 mmol/1 glucose
100.0 ng/ml leptin
7.53 ± 0.31 39.65 ± 3.37
11.0 mmol/1 glucose
10.0 nmol/1 GLP-I
13.87 ± 1.01 59.19 ± 6.11
11.0 mmol/1 glucose
10.0 nmol/1 GLP-I
100.0 ng/ml leptin
14.06 ± 1.17 59.98 ± 1.88

Data are means ± SE; n = 7; GLP-I, n = 4.

*

P < 0.0007

P < 0.022 compared with controls in the absence of leptin using Student’s paired t test.