Table 4.
—Association of Plasma Biomarker Measurements at Baseline With Death
| Variable (pg/mL) | Odds Ratio of Death (95% CI)a | VFDs (Mean Difference, Days) (95% CI)b | OFDs (Mean Difference, Days) (95% CI)b |
| IL-6 | 1.10 (1.02-1.19) | −0.99 (−1.33 to −0.65) | −1.23 (−1.56 to −0.90) |
| IL-8 | 1.30 (1.17-1.44) | −1.34 (−1.77 to −0.90) | −1.62 (−2.05 to −1.20) |
| TNF-α receptor 1 | 1.48 (1.24-1.76) | −1.07 (−1.86 to −0.27) | −4.02 (−4.76 to −3.28) |
| SP-D | 1.35 (1.18-1.55) | −1.08 (−1.65 to −0.50) | −0.64 (−1.21 to −0.07) |
| sICAM | 1.11 (0.94-1.33) | −0.62 (−1.37 to 0.14) | −0.93 (−1.67 to −0.19) |
| vWF | 1.50 (1.21-1.85) | −0.53 (−1.42 to 0.35) | −1.08 (−1.95 to −0.21) |
| Protein C | 0.74 (0.61-0.91) | 2.24 (1.36-3.13) | 2.74 (1.88-3.61) |
| PAI-1 | 1.20 (1.06-1.36) | −0.91 (−1.48 to −0.34) | −0.98 (−1.54 to −0.41) |
a
Logistic regression models include natural log-transformed cytokine levels with adjustment for gender, APACHE III score, comorbid diabetes, ALI risk factor, and tidal volume assignment. Odds ratio is expressed per natural log increment of cytokine level.
b
Linear regression models include natural log-transformed cytokine levels with adjustment for gender, APACHE III score, comorbid diabetes, ALI risk factor, and tidal volume assignment. Days are expressed per natural log increment of cytokine level.