Figure 2.

Serum VEGF-D levels are elevated in S-LAM in the absence of angiomyolipomas (AMLs) or chylous effusions and distinguish lone LAM from other cystic lung diseases that mimic LAM. (A) Serum VEGF-D levels in lone LAM vs other cystic lung diseases in the differential diagnosis. Subjects with lone LAM (n = 19) lacked other corroborating disease features, such as tuberous sclerosis complex (TSC), AMLs, or chylous effusions, and were all diagnosed by biopsy. Lines denote median values for each group. (B) ROC curve for lone LAM vs other cystic lung diseases. The area under the ROC curve is 0.940 ± 0.034 (95% CI, 0.873-1.0). See Figure 1 legend for expansion of abbreviations.