Figure 5.

Test performance of serum VEGF-D levels in discriminating the presence or absence of LAM in women with TSC, an at-risk population. (A) Results of VEGF-D testing in women with TSC-LAM (n = 28) vs women with TSC only (n = 17). Women with TSC only were defined as those with the absence of cysts on chest scan within 18 months of VEGF-D testing. Lines denote median values for each group, and performance at proposed cut-off values is shown. Note that the dotted line indicates that a higher cut-off value of 900 pg/mL would be needed to achieve 100% specificity in this setting. (B) ROC curve for VEGF-D in women with TSC-LAM vs TSC only. Area under the ROC curve is 0.992 ± 0.010 (95% CI, 0.973-1.0). See Figure 1 and 2 legends for expansion of abbreviations.