Table 5.
Tumor Stage of Invasive Cancers by BIRADS Density Dependent on Menopausal Status
| Variable | No. | % | Tumor Stage* |
Analysis Comparing Advance to Early Stage Cancer† |
||||
|---|---|---|---|---|---|---|---|---|
| I | IIA | IIB | III or IV | OR | 95% CI | |||
| All women | ||||||||
| No. | 10,514 | 6,262 | 4,645 | 1,045 | 916 | |||
| BIRADS‡ | ||||||||
| 1 | 664 | 6.3 | 68.9 | 17.5 | 6.0 | 7.6 | 0.74 | 0.57 to 0.94 |
| 2 | 4,645 | 44.2 | 62.6 | 20.3 | 8.9 | 8.1 | 1.00 | |
| 3 | 4,799 | 45.6 | 57.1 | 23.2 | 10.8 | 8.9 | 1.25 | 1.11 to 1.40 |
| 4 | 1,075 | 10.2 | 51.6 | 24.1 | 12.9 | 11.4 | 1.60 | 1.33 to 1.91 |
| Premenopausal | ||||||||
| No. | 2,277 | 1,145 | 636 | 310 | 236 | |||
| BIRADS‡ | ||||||||
| 1 | 36 | 1.6 | 54.5 | 30.3 | 6.1 | 9.1 | 0.47 | 0.17 to 1.26 |
| 2 | 636 | 27.9 | 50.4 | 26.0 | 13.6 | 10.1 | 1.00 | |
| 3 | 1,256 | 55.2 | 51.4 | 25.8 | 13.1 | 9.8 | 1.18 | 0.92 to 1.50 |
| 4 | 503 | 22.1 | 47.1 | 25.1 | 15.5 | 12.3 | 1.71 | 1.26 to 2.31 |
| Postmenopausal and no HT | ||||||||
| No. | 4,980 | 3,139 | 2,717 | 423 | 412 | |||
| BIRADS‡ | ||||||||
| 1 | 504 | 10.1 | 68.5 | 17.4 | 6.2 | 7.9 | 0.81 | 0.61 to 1.08 |
| 2 | 2,717 | 54.6 | 65.0 | 18.9 | 8.1 | 8.0 | 1.00 | |
| 3 | 1,848 | 37.1 | 59.3 | 22.7 | 9.6 | 8.5 | 1.21 | 1.02 to 1.44 |
| 4 | 251 | 5.0 | 58.8 | 21.8 | 9.7 | 9.7 | 1.32 | 0.93 to 1.88 |
| Postmenopausal and HT | ||||||||
| No. | 3,257 | 1,978 | 1,292 | 312 | 268 | |||
| BIRADS‡ | ||||||||
| 1 | 124 | 3.8 | 74.6 | 14.4 | 5.1 | 5.9 | 0.60 | 0.33 to 1.10 |
| 2 | 1,292 | 39.7 | 63.7 | 20.7 | 8.5 | 7.2 | 1.00 | |
| 3 | 1,695 | 52.0 | 59.0 | 22.0 | 10.4 | 8.6 | 1.37 | 1.12 to 1.69 |
| 4 | 321 | 9.9 | 52.9 | 24.4 | 11.4 | 11.4 | 1.75 | 1.27 to 2.42 |
Abbreviations: BIRADS, Breast Imaging Reporting and Data System; OR, odds ratio; HT, hormone therapy; BMI, body mass index.
Row percentages.
Four separate logistic regression models for the binary outcome advanced stage cancer (IIB, III, or IV) versus early stage (I and IIA) adjusted for age, BMI, BMI2, HT, menopausal status (for All Women model only), and registry. All predictors were measured at the most recent screening examination prior to breast cancer diagnosis.
BIRADS density 1 = almost entirely fat (low breast density); 2 = scattered fibroglandular densities (average breast density); 3 = heterogeneously dense (high breast density); 4 = extremely dense (very high breast density).