TABLE 1.
Genes Significantly Modified by HD Coexposure
| Gene symbol | Gene description | HD effect | Linear x-ray effect | Type of interaction |
| IER3 | Immediate early response 3 | 6.7233 | −0.0574 | Antagonistic |
| ANGPTL4 | Angiopoietin-like 4 | 6.0360 | −0.2983 | Antagonistic |
| CTGF | Connective tissue growth factor | 3.6301 | −0.1609 | Antagonistic |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 1.9441 | −0.0471 | Antagonistic |
| TLE3 | Transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila) | 1.8419 | −0.0077 | Antagonistic |
| MLF2 | Myeloid leukemia factor 2 | 1.0791 | 0.0135 | Agonistic |
| CD53 | CD53 molecule | −0.3673 | 0.0063 | Antagonistic |
| SSRP1 | Structure-specific recognition protein 1 | −0.3705 | −0.0393 | Agonistic |
| THAP4 | THAP domain containing 4 | −0.4876 | −0.0301 | Agonistic |
| MBD3 | Methyl-CpG-binding domain protein 3 | −0.5390 | −0.0220 | Agonistic |
| PRKAG2 | Protein kinase, AMP-activated, gamma 2 noncatalytic subunit | −0.5841 | −0.0284 | Agonistic |
| CAMSAP1 | Calmodulin-regulated spectrin-associated protein 1 | −0.6200 | −0.0391 | Agonistic |
| RANBP10 | RAN-binding protein 10 | −0.7035 | 0.0026 | Antagonistic |
| NASP | Nuclear autoantigenic sperm protein (histone binding) | −0.7701 | −0.0432 | Agonistic |
| LRRC48 | Leucine-rich repeat containing 48 | −0.7934 | −0.0725 | Agonistic |
| GPI | Glucose phosphate isomerase | −0.8050 | −0.1152 | Agonistic |
| FBP1 | Fructose-1,6-bisphosphatase 1 | −0.8497 | −0.0416 | Agonistic |
| DHRSX | Dehydrogenase/reductase (SDR family) X-linked | −0.8555 | −0.0908 | Agonistic |
| JTV1 | JTV1 gene | −0.8961 | −0.0647 | Agonistic |
| RGD1306603 | — | −0.9134 | −0.0432 | Agonistic |
| ITPKA | Inositol 1,4,5-trisphosphate 3-kinase A | −0.9262 | −0.0571 | Agonistic |
| RGD1311084 | Similar to 1700113K14Rik protein | −0.9977 | −0.0894 | Agonistic |
| RGD1309730 | Similar to RIKEN cDNA B230118H07 | −0.9983 | −0.0825 | Agonistic |
| PGAM2 | Phosphoglycerate mutase elevated 2 | −1.0061 | −0.0485 | Agonistic |
| DNMBP | Dynamin-binding protein | −1.0160 | −0.0360 | Agonistic |
| PASK | PAS domain containing serine/threonine kinase | −1.0413 | −0.0475 | Agonistic |
| MRPS11 | Mitochondrial ribosomal protein S11 | −1.0454 | −0.0264 | Agonistic |
| RCG_20380 | Hypothetical protein LOC100125367 | −1.0698 | −0.0177 | Agonistic |
| DDI2 | DDI1, DNA-damage inducible 1, homolog 2 (Saccharomyces cerevisiae) | −1.1447 | −0.0276 | Agonistic |
| CNTF | Ciliary neurotrophic factor | −1.1486 | −0.0537 | Agonistic |
| FOXK1 | Forkhead box K1 | −1.1508 | −0.0395 | Agonistic |
| H2AFJ | H2A histone family, member J | −1.1984 | −0.0711 | Agonistic |
| RNPEP | Arginyl aminopeptidase (aminopeptidase B) | −1.2364 | −0.0427 | Agonistic |
| HDDC3 | HD domain containing 3 | −1.2622 | −0.1110 | Agonistic |
| PRSS21 | Protease, serine, 21 (testisin) | −1.2652 | −0.0599 | Agonistic |
| SHANK3 | SH3 and multiple ankyrin repeat domains 3 | −1.2974 | −0.0321 | Agonistic |
| PITPNM1 | Phosphatidylinositol transfer protein, membrane-associated 1 | −1.3852 | −0.1325 | Agonistic |
| CYGB | Cytoglobin | −1.3958 | 0.0049 | Antagonistic |
| MAP3K11 | Mitogen-activated protein kinase kinase kinase 11 | −1.4775 | −0.1093 | Agonistic |
| PEX14 | Peroxisomal biogenesis factor 14 | −1.4910 | −0.0197 | Agonistic |
| DNAH1 | Dynein, axonemal, heavy chain 1 | −1.5618 | −0.1265 | Agonistic |
| COMP | Cartilage oligomeric matrix protein | −1.6105 | −0.0754 | Agonistic |
| LMOD2 | Leiomodin 2 (cardiac) | −1.6165 | −0.0933 | Agonistic |
| LOC499124 | Mouse zinc finger protein 14-like | −1.6318 | −0.0278 | Agonistic |
| CAPG | Capping protein (actin filament), gelsolin-like | −1.6775 | −0.1963 | Agonistic |
| COL6A1 | Collagen, type VI, alpha 1 | −1.7034 | −0.0436 | Agonistic |
| HSPB1 | Heat shock 27 kDa protein 1 | −2.0133 | −0.0698 | Agonistic |
| DPP7 | Dipeptidyl-peptidase 7 | −2.0200 | −0.1500 | Agonistic |
| MACROD1 | MACRO domain containing 1 | −2.0658 | −0.1446 | Agonistic |
| ALKBH2 | alkB, alkylation repair homolog 2 (Escherichia coli) | −2.1629 | −0.0629 | Agonistic |
| CFC1 | Cripton, FRL-1, cryptic family 1 | −2.5058 | −0.0155 | Agonistic |
| LOC683980 | Similar to keratinocytes associated protein 3 | −2.9492 | −0.1152 | Agonistic |
| LOXL1 | Lysyl oxidase-like 1 | −3.1699 | −0.1629 | Agonistic |
| CLCA2 /// CLCA4L | Chloride channel calcium activated 2 /// chloride channel calcium activated 4-like | −3.2185 | −0.3286 | Agonistic |
| GHSR | Growth hormone secretagogue receptor | −3.3223 | −0.0963 | Agonistic |
Note. The genes included in this table meet the significance threshold of FDR < 0.05 for the HD Effect. An agonistic interaction indicates an HD effect and x-ray effect in the same direction, whereas an antagonistic interaction indicates an HD effect and x-ray effect in opposing directions.