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Necrotic cell death measured by LDH release in primary mouse hepatocytes treated with 5mM APAP after 15 h at various oxygen concentrations. Experiments were carried out as described in the Materials and Methods section. Values represent mean ± SE of n = 3 independent experiments. *p < 0.05 (when compared with respective control) and #p < 0.05 (compared with APAP-treated samples at 21% oxygen).
