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Necrotic cell death measured by LDH release in primary mouse hepatocytes treated with 5mM APAP after 15 h at various oxygen concentrations. Some of the cells were pretreated for 1 h with 50μM α-tocopheryl succinate (Vit E) and 20μM BHT. Values represent mean ± SE of n = 3 independent experiments. *p < 0.05 (when compared with respective APAP control).
