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. 2010 Jun 23;24(8):1543–1558. doi: 10.1210/me.2009-0381

Figure 6.

Figure 6

Uhmk1 tethering to membranes does not prevent nuclear expulsion of PAM-CD. A, AtT-20 cells were cotransfected with vectors encoding mycCD and GFP-Farnesyl or mycCD and Uhmk1-Farnesyl. B, Ratio between the nuclear and the cytoplasmic intensities of the cotransfected cells in panel A; P < 0.001. C, AtT-20 cells were cotransfected with vectors encoding mycCD and GFP-MARCKS or mycCD and Uhmk1-MARCKS. D, Ratio between the nuclear and the cytoplasmic intensities of the cotransfected cells in panel C; P < 0.05. Even when tethered to a membrane anchor, Uhmk1 diminished the ability of mycCD to accumulate in the nucleus. Mean ± sem, nine to 16 cells per bar. MARCKS, Myristoylated alanine-rich C-kinase substrate.