Figure 8.

ChIP-Seq identifies Foxa-regulatory regions in ChREBP. A, Foxa2 ChIP-Seq using E14.5 and islet chromatin demonstrates significant binding to two conserved regulatory regions within the first intron of ChREBP gene. Consensus Foxa-binding sites (boxed) are shown within the two regions. Strong occupancy of region II is islet enriched. B, Quantitative ChIP assays for Foxa1 and Foxa2 were performed using chromatin derived from a time course of wild-type developing pancreas and adult islets. *, P < 0.05; #, P < 0.01. Panc., Pancreas.