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. 2010 Jul 21;24(9):1748–1764. doi: 10.1210/me.2010-0192

Figure 2.

Figure 2

AICAR differentially regulates the transcriptional activity of glucocorticoid-responsive genes in a tissue- and gene-specific fashion. Rats were treated with AICAR (0.7 g/kg per animal) and/or dexamethasone (1.5 mg/kg per animal) for 8 h, and mRNA expression of GILZ, PEPCK, and G6Pase were examined with SYBR Green-based real-time PCR. the fold induction of mRNA expression of the indicated genes was calculated by dividing values of the mRNA expression with that of the baseline (the value obtained in the absence of AICAR and dexamethasone). Bars represent mean ± se values of the fold induction of mRNA expression in the presence or absence of dexamethasone. See main text for results of statistical analyses.