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A possible role for chromatin structure in HIV-1 DNA integration. HIV-1 DNA integration occurs preferentially in the vicinity of certain epigenetic modifications, such as H3 K4 methylation (H3K4Me) and H3 and H4 acetylation (H3-Ac and H4-Ac, respectively). Integration seems to be disfavored in the vicinity of H3K27 trimethylation (H3K27Me3) and CpG islands in the DNA (see text and Wang et al., 2007).
