Skip to main content
. 2010 Jul 21;151(9):4477–4484. doi: 10.1210/en.2010-0177

Figure 2.

Figure 2

E2 enhances the KATP channel activity through activation of PKA. A, A representative recording showing that treatment of GnRH cells with 5 μm forskolin for 15 min enhanced the diazoxide-induced KATP current by 2.4-fold. B, Pretreatment with 10 μm H89 for 10 min before E2 (100 nm) treatment prevented the potentiating effects of E2 on the KATP channel activity. C, Summary of the effects of forskolin (FSK; 5 μm), H89 (10 μm) and BIS (1 μm) on the E2 (100 nm)-induced potentiation of the KATP channel activity in GnRH neurons from oil-treated mice. **, P < 0.01, compared with control group; ##, P < 0.01, compared with E2 group. Cell numbers are indicated on the bars.