Skip to main content
. 2010 Jun 23;151(9):4494–4503. doi: 10.1210/en.2010-0223

Figure 2.

Figure 2

Circulating concentrations of LH (mean ± sem) after the last GnRH (G) pulse of the priming infusion (open arrow) and sequential bolus iv injections (arrows) of senktide (S) (50 μg), NKB (N) (100 μg), and GnRH (0.3 μg) (black arrows) given at 2-h intervals to agonadal juvenile male monkeys when a GnRH-R antagonist, acyline (A) (arrowhead), was given 30 min after the first GnRH challenge (closed data points). Note the absence of LH discharges in response to the three peptides after administration of acyline. Treatment with the vehicle for the GnRH-R antagonist (V) (5% mannitol in saline; arrowhead) did not interrupt the LH discharge induced by a bolus iv injection of senktide (open data points). The response to NKB and the second GnRH challenge was not studied after vehicle administration. n = 4.