Figure 4.

Loss of CCK causes a diabetogenic phenotype. Fasting plasma glucose (A) and plasma insulin (B) levels of male and female 6-wk-old (n = 161–163), 10-wk-old (n = 155–168), and 14-wk-old (n = 75–105) Cck^WT-ob/ob and Cck^lacZ-ob/ob mice. Glucose and insulin values were log₁₀ transformed. Comparisons were made by nested ANOVA adjusting for sex, genotype, time, and their interactions. For fasting glucose (A), no interactions of sex or time with genotype existed. For fasting insulin (B), genotype and sex interactions were not significant, but time by genotype interactions were significant (P = 0.012).