Table 2.
CNAs identified in 18 pGBMs and aGBMs using the 100K SNP Illumina array
| Tumors | No of CNAs | CNAs |
|---|---|---|
| P1 | 1 | (−)22q |
| P2 | 12 | (−)2q11-13, (−)9p24-21, (−)10p12-11, (−)10q, (−)14q23-32, (−)15q15-14, (−)16q, (−)17p, (+)17q21-25, del17q11, (−)19q, del21q11-21 |
| P3 | 2 | (−)12q24, (−)22q |
| P4 | 38 | (−)2p25-11, (−)3q21-29, (−)4p16-13, (−)4p12, (+)4p13, (+)4p12, (−)4q13-35,(+)4q12, (+)5p33-15, (+)5p15-12 (−)5p15, (−)5q11-21, (−)5q31-32, (del)6q24, (−)7p, (−)7q, (+)7q31, (−)9p22-21, (+)9p24, (+)9p23-22, (+)9p21-13, (+)10p12, (−)10q11-23, (+)10q23-24, (−)10q24-26,del11q11-22, del11q22-23, (−)12q21-23, (−)13q, (−)14q, del16q23, (−)17p13-17q11, (−)18p, (−)18q, (−)19p13, (+)19p13, (−)20q, (−)22q |
| P5 | 4 | (+)2p24, (+)11p, (−)11q13-25, (+)17q21-24 |
| P6 | 6 | (+)1q, (−)8p23, (−)9p, (+)9q, (+)21q21, (−)22q12-13 |
| P7 | 23 | (−)3p, (−)3q, (−)4p, (−)4q, (−)5p, (−)5q, (−)6p, (−)6q, (+)7q21, (−)8p, (−)8q, (+)9q33-34, (−)10p, (+)10p12, (−)10q, (+)13q14, (+)13q31, (+)13q33-34, (−)15q, (−)17p, (−)17q, (−)19p13, (−)22q |
| P8 | 33 | (+)1q43-44, (−)2p24-23, (+)2p25, (+)2p24.3, (+)2p24.1, (+)2p23.1, (−)3p, (−)3q,(+)3q26, (−)4p,(−)4q, (−)5p, (−)5q, (−)6p, (−)6q, (+)7p11, (+)7q21, (+)7q21, (+)7q31, (+)7q33, (−)8p, (−)8q, (−)10p, (−)10q, (−)11p15, (−)11q13-23 |
| (−)14q, (−)15q, (−)17p, (−)17q, (−)18p, (−)18q, (−)22q | ||
| P9 | 33 | (−)1p, (−)1q, (−)2p, (−)2q, del2q21-22, (−)3p, (−)3q, (−)4q32-35, (−)5q15-35, (−)6p, (−)6q, (−)8q11-24, (−)8q24, (−)9p, del9p23, del9p21, (−)9q, (−)10p, (−)10q, (+)10q26, (−)11p, (−)11q, (−)13q, (−)14q, (−)16p, (−)16q, (−)17p, (−)17q, (−)18p, (−)18q, (−)20p, (−)20q, (−)21q |
| P10 | 17 | (−)2p, (−)3q12-27, (+)3q26-29, (−)4q31, (+)7p, (+)7q, (−)8p21-12, (−)8p12-11, (−)9p21-13, 9q31-33, (−)10p, del 10q21-22, (−)10q25-26, (−)11q22-24, (−)14q31-32, (−)17p13, (−)19q13 |
| P11 | 4 | (−)1p, (−)6q12-13, (+)6q14, (−)6q14-27 |
| P12 | 4 | (−)10q21-26, (−)15q12-26, (−)16p, (+)17p13 |
| P13 | 15 | del1q24-31, (+)5p15, (+)7p22, (+)7p21, (+)7p21, (−)9p24-22, (−)9p21, (−)10q23-26, (+)10q22, (+)10q23, (−)16q, (−)17p, (−)18q12-23, (−)20p, (−)21q |
| P14 | 1 | (−)22q |
| P14 | 4 | (+)2p24, (+)4q12, (+)7p, (+)7q |
| P16 | 1 | (+)9p21-13 |
| P17 | 1 | (+)7q11 |
| P18 | 0 | |
| A1 | 10 | (+)3p11-12, (−)3p26-24, (−)3q27-28, (−)3q29, (−)9p, del9p22-21, (−)9q12-21, (−)10p, (−)10q, (−)22q12-13 |
| A2 | 14 | (−)3p26, (−)9p24-21, (−)9p21, (−)9p13, (−)9q22, (−)11p15, 12p13-12, (−)13q12-21, del 14q23, del14q24, (−)10p, (−)10q, (−)17p13, (−)19q13, (−)21q, (−)22q13 |
| A3 | 3 | (−)4q13-35, (−)9p24-21 |
| A4 | 4 | (+)7p11-14; del 9p22-21, (−)10q, (+)12q13-15, (−)19p12 |
| A5 | 9 | (−)5q, (−)7q11-21, (−)11p15-11, (−)12p, (−)13q, (−)14q, (−)17p13-11, (−)18p11, (−)21q22 |
| A6 | 2 | (+)7p14-15, (+)7p11-15, (−)10q |
A, adult glioblastoma; P, pediatric glioblastoma. (−) indicates an LOH; (+) indicates an amplification or gain; “del” indicates a homozygous deletion.