Fig. 5.

Treatment of experimental glioma with chloroquine in vivo. Tumor volumes and mitotic and apoptotic indexes were determined in chloroquine- or PBS-treated U87MG tumors as described in the Materials and Methods section. (A) Chloroquine-treated tumors show a significant decrease in the average tumor volume and a lower mitotic index, but significantly elevated rates of apoptotic cells. The data analysis was performed using a one-way analysis of variance. (B) Representative hematoxylin/eosin-stained histological sections. The arrowheads indicate mitotic cells. (C) Representative TUNEL-stained histological sections. The arrowheads indicate TUNEL-positive cells.