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Glioma cell lines induce FasL dependent T-cell death in vitro. LDH release was measured after FasL sensitive, PHA activated T-cells were cocultured with FasL expressing glioma cell lines in the absence (black bars) or presence (white bars) of a FasL neutralizing antibody (MFL4). The results indicate that up to 30% of T-cell death was inhibited by the FasL neutralizing antibody and thus mediated by FasL.
