Table 1.
Summary of the roles of ezrin, NF2, and chimeric ezrin-NF2 proteins in GBM cells
| Protein | Proliferation colony formation | Cell shape | Intracellular localization |
||
|---|---|---|---|---|---|
| Immunofluorescence | Coloc. P-ERM | Fractionation | |||
| Ezrin | ↑ | Elongated | Cytoplasm | No | Cyt. |
| NF2 | ↓ | Unchanged | Memb-cell junctions | n.t. | TX-sol/Cyt. |
| Ez/NF2 | ↑ | Spread | Memb-spikes | Yes | TX-sol/TX-insol |
| NF2/Ez | ↓ | Unchanged | Memb-cell junctions | n.t. | TX-sol/Cyt. |
| EzΔ53 | n.t. | Spread | Memb-spikes | n.t. | TX-sol/TX-insol |
↑, increase; ↓, decrease; n.t., not tested; Coloc, colocalization; memb, membrane; Cyt., cytoplasm, TX-sol, Triton-X soluble; TX-insol, Triton-X insoluble.