Fig. 6.

PTEN suppresses the in vivo tumor growth and proliferation of both SPARC-expressing and control GBM cells and increases blood vessel size and vascular area in control but not in SPARC-expressing tumors. Intracranial xenografts were quantitated and analyzed statistically for tumor volume (A), proliferation index (B), number of blood vessels (C), total vascular area (D), and median vessel size (E). AU, arbitrary units. Asterisks denote significantly different from C2a2_EV (unless otherwise indicated) where * = P < 0.05, ** = P < 0.001, n = 6 animals/group.