Table 3.
Genes (n = 47) differentially expressed in the three groups of GBM identified by their GEP
| Gene name | Gene symbol | Chromosomal localization | GEP tumor groups |
||
|---|---|---|---|---|---|
| GEP 1 | GEP 2 | GEP 3 | |||
| Duffy blood group, chemokine receptor | DARC | 1q21–q22 | − | + | + |
| Leucine-rich repeat containing G protein-coupled receptor 6 | LGR6 | 1q32.1 | − | + | − |
| Ryanodine receptor 2 (cardiac) | RYR2 | 1q42.1–q43 | − | + | − |
| Potassium channel, subfamily K, member 1 | KCNK1 | 1q42–q43 | − | + | − |
| Bone morphogenetic protein receptor, type II | BMPR2 | 2q33–q34 | + | − | − |
| Synapsin II | SYN2 | 3p25 | − | + | − |
| Myosin, light chain kinase | MYLK | 3q21 | − | + | + |
| Replication factor C (activator 1) 4, 37 kDa | RFC4 | 3q27 | + | − | + |
| G protein-coupled receptor 125 | GPR125 | 4p15.31 | + | − | − |
| Spermatogenesis associated 18 homolog | SPATA18 | 4q12 | − | + | − |
| Synuclein, alpha | SNCA | 4q21 | − | + | − |
| Disabled homolog 2, mitogen-responsive phosphoprotein | DAB2 | 5p13 | − | + | + |
| EGF-like repeats and discoidin I-like domains 3 | EDIL3 | 5q14 | − | + | + |
| Lamin B1 | LMNB1 | 5q23.3–q31.1 | + | − | + |
| Gamma-aminobutyric acid (GABA) A receptor, beta 2 | GABRB2 | 5q34 | − | + | − |
| Gamma-aminobutyric acid (GABA) A receptor, alpha 1 | GABRA1 | 5q34–q35 | − | + | − |
| Hypothetical protein LOC202134 | LOC202134 | 5q35.2 | − | + | − |
| Ectonucleotide pyrophosphatase/phosphodiesterase 4 | ENPP4 | 6p12.3 | − | + | + |
| Protein kinase C and casein kinase substrate in neurons 1 | PACSIN1 | 6p21.3 | − | + | − |
| Leucine rich repeat containing 16 | LRRC16 | 6p22.2 | + | + | − |
| Sec61 gamma subunit | SEC61G | 7p11.2 | + | − | − |
| Epidermal growth factor receptor | EGFR | 7p12 | + | − | − |
| Dedicator of cytokinesis 5 | DOCK5 | 8p21.2 | − | + | + |
| Discs, large (Drosophila) homolog-associated protein 2 | DLGAP2 | 8p23 | − | + | − |
| Sulfatase 1 | SULF1 | 8q13.2–q13.3 | − | + | + |
| Cytochrome P450, family 7, subfamily B, polypeptide 1 | CYP7B1 | 8q21.3 | − | + | + |
| Ectonucleotide pyrophosphatase/phosphodiesterase 2 | ENPP2 | 8q24.1 | − | + | + |
| Growth arrest-specific 1 | GAS1 | 9q21.3–q22 | + | − | − |
| Regulator of G protein signaling 3 | RGS3 | 9q32 | − | + | − |
| Calcium channel, voltage-dependent, N type, alpha 1B subunit | CACNA1B | 9q34 | − | + | − |
| Prostaglandin D2 synthase | PTGDS | 9q34.2–q34.3 | − | + | + |
| Glutamate decarboxylase 2 | GAD2 | 10p11.23 | − | + | − |
| KIAA1462 | KIAA1462 | 10p11.23 | − | + | − |
| Solute carrier family 39 (zinc transporter), member 12 | SLC39A12 | 10p12.33 | − | + | − |
| Hypothetical protein DKFZp313A2432 | DKFZp313A2432 | 11p14.2 | − | + | + |
| Transmembrane protein 16E | TMEM16E | 11p14.3 | − | + | + |
| Murine retrovirus integration site 1 homolog | MRVI1 | 11p15 | − | + | − |
| Microtubule associated monoxygenase, calponin and LIM 2 | MICAL2 | 11p15.3 | − | + | − |
| DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 | DDX11 | 12p11 | + | − | + |
| RAS-like, estrogen-regulated, growth inhibitor | RERG | 12p12.3 | − | + | − |
| Calcium channel, voltage-dependent, L type, alpha 1C | CACNA1C | 12p13.3 | − | + | − |
| Suppressor of cytokine signaling 2 | SOCS2 | 12q | + | − | − |
| Gap junction protein, beta 6 | GJB6 | 13q11–q12.1 | − | + | − |
| Embryonal Fyn-associated substrate | EFS | 14q11.2–q12 | + | − | + |
| Solute carrier family 17, member 7 | SLC17A7 | 19q13 | − | + | − |
| Ferritin, light polypeptide | FTL | 19q13.3–q13.4 | − | + | + |
| DiGeorge syndrome critical region gene 14 | DGCR14 | 22q11.21 | + | − | + |
Abbreviations: GBM, glioblastoma multiforme; GEP, gene expression profiles.