Table 5.
Clinical and cytogenetic characteristics of glioblastoma multiforme (GBM) patients grouped according to their tumoral gene expression profiles (GEP)
| GEP group |
P-value | |||
|---|---|---|---|---|
| GEP 1 (n = 8) | GEP 2 (n = 5) | GEP 3 (n = 13) | ||
| Age | ||||
| <40 years | 0/8 | 3/5 | 0/13 | 0.001 |
| >40 years | 8/8 | 2/5 | 13/13 | |
| Gender | ||||
| Male | 3/8 | 1/5 | 9/13 | 0.12 |
| Female | 5/8 | 4/5 | 4/13 | |
| Karnofsky indexa | 70 ± 12 (60–90) | 76 ± 9 (60–80) | 67 ± 10 (50–80) | 0.26 |
| Tumor localization | ||||
| Frontal | 3/8 | 1/5 | 4/13 | 0.50 |
| Temporal | 1/8 | 3/5 | 5/13 | |
| Multilobular | 4/8 | 1/5 | 4/13 | |
| Ancestral tumor cell clone | ||||
| Amp7 | 8/8 | 0/0 | 0/0 | <0.001 |
| +7q or +7p | 0/0 | 5/5 | 0/0 | |
| +7 | 0/0 | 0/0 | 4/13 | |
| −9p/−9p | 0/0 | 0/0 | 3/13 | |
| −10q | 0/0 | 0/0 | 2/13 | |
| +7p–9p | 0/0 | 0/0 | 4/13 | |
| Number of tumor cell clonesa (by iFISH) | 6 ± 2 (4–9) | 4 ± 1 (3–5) | 4 ± 1 (3–7) | 0.09 |
| Median OS (months)b | 13 ± 4 (8–18) | 16 ± 8 (5–25) | 6 ± 7 (0–25) | 0.05 |
| Number of relapses | 2/8 | 3/5 | 0/13 | 0.01 |
| Number of deaths | 3/8 | 4/5 | 10/13 | 0.14 |
Abbreviation: OS, overall survival. Results expressed as number (N) of cases/total cases.
aMean ± one standard deviation (SD).
bMedian and range between brackets.