Table 3. SNPs associated with CSF ptau₁₈₁ levels in the initial series, the replication series and the combined dataset.

gene	rs	MAF	WU-ADRC-CSF		Replication series		Combined Series
			uncorrected	FDRp-value	uncorrected	FDRp-value	uncorrected	effectc
PPP3R1	rs1868402A	0.37	5.90×10−04	0.025	0.005	0.034	1.17×10−05*	−0.30 (0.06)
PPP3R1	rs6546366A	0.35	0.004	0.030	0.271	0.476	0.003	−0.24(0.08)
F2	rs2070852A	0.32	0.008	0.041	0.690	0.523	0.114	−0.14 (0.08)
FYN	rs927010B	0.26	5.92×10−04	0.025	0.425	0.476	0.081	−0.26 (0.17)
FYN	rs7768046	0.39	0.004	0.030	0.465	0.476	0.107	−0.08 (0.06)
GSK3β	rs3755557B	0.12	0.004	0.030	0.442	0.476	0.794	0.06 (0.30)
GSK3β	rs7431209A	0.24	0.005	0.030	0.946	0.587	0.590	0.03 (0.08)
MAPT	rs7210728A	0.36	0.005	0.041	0.529	0.476	0.110	0.11 (0.08)
MGEA5	rs2305192B	0.30	0.008	0.041	0.795	0.542	0.046	−0.31 (0.14)
PRKCA	rs7218425	0.21	0.005	0.030	0.358	0.476	0.218	0.07 (0.07)

NPs that passed FDR correction in the WU-ADRC-CSF series were followed up in a replication series composed of CSF samples from ADNI-CSF and UW. Both series (WU-ADRC-CSF and Replication) were combined to increase the statistical power. In the WU-ADRC-CSF and replication series; p-values in bold denote values that are significant after FDR correction. In the Combined Series we applied Bonferroni correction. Threshold for Bonferroni correction is 1.3×10⁻⁰⁴.

For each SNP the rs number and P values for association with ptau₁₈₁ before and after FDR correction are shown.

^ADominant model.

^BRecessive model.

^Ceffects and the standard error of the mean are given in units of standard deviation.