Table 6. Association with rate of disease progression.

	WU-ADRC-CSF	ADNI-CSF	Combined CSF series	ADNI samplesNo CSF
rs1868402	0.0026	0.014	1.71×10−05	0.0187
rs1868402*rs3785883	4.00×10−04	0.010	1.43×10−05	0.0123

Rs1868402 is associated with progression rate and shows epistasis with rs3785883, which is also associated with CSF tau levels [27].

Rate of progression were analyzed by the change of the Clinical Dementia Rating sum of boxes (CDR-SB) score per year in individuals with low CSF Aβ₄₂ levels (ADRC<500pg/ml; ADNI<192pg/ml) and in samples with no CSF data. Association of SNPs with progression was calculated with mixed linear models (proc mixed) after controlling for age, sex, APOE, CDR and/or CSF ptau₁₈₁ and Aβ₄₂.