Table 1.
Details of bisphosphonate-treated cases
| Sex/Age | Tumour Site | Pre treatment Recurrence/Metastasis | Post treatment Follow-up (months) | Type of bisphosphonate (and other) treatment employed | Post treatment Radiological/Clinical Outcome |
|---|---|---|---|---|---|
| 1. M 39 | Distal femur | RRR/- | 24 | Alendronate | Pain decrease No further recurrence |
| 2. F 28 | Sacrum | */- | 36 | Clodronate (Interferon α, Radiation) | Pain decrease Stable size |
| 3. M 63 | Distal femur | R/M | 12 | Clodronate (Interferon α) | No further recurrence Lung mets stable |
| 4. M 16 | Distal Femur, Proximal Femur, Proximal Tibia (Multifocal) | R/M | 60 | Clodronate (Interferon α, Cis-platin, Adriamycin) | Stable size Lung mets stable |
| 5. M 20 | Proximal Femur | RR/M | 64 | Pamidronate (Interferon α) | No further recurrence Lung mets stable |
| 6. M 47 | Pelvis | R/- | 50 | Clodronate (Radiation) | Stable size |
| 7. F 56 | Sacrum | R/- | 32 | Alendronate (Radiation, Embolisation) | Pain decrease Stable size |
| 8. F 75 | Sacrum | */- | 24 | Zoledronic acid | Stable size |
| 9. F 42 | Proximal Femur | RRRRR/- | 24 | Zoledronic acid | No further recurrence Pain decrease |
| 10. M 34 | Vertebra | RR/- | 12 | Zoledronic acid (Radiotherapy, Embolisation) | Stable size Recurrence |
| 11. M 32 | Fibula | RR(ST)/M | 62 | Zoledronic acid | Pain decrease No further recurrence Lung mets stable |
| 12. F 21 | Sacrum | RR/- | 60 | Zoledronic acid (Embolisation) | Disease progression |
| 13. F 45 | Sacrum | M | 12 | Zoledronic acid (Embolisation) | Decrease in size Pain decrease |
| 14. M 74 | Pelvis | */- | 26 | Zoledronic acid (Embolisation) | Pain decrease Stable size Paget's |
| 15. F 19 | Sacrum | R/- | 15 | Zoledronic acid (Embolisation) | Stable size No further recurrence |
| 16. F 48 | Sacrum | R/- | 24 | Zoledronic acid a (Embolisation) | Stable size No further recurrence |
| 17. M 15 | Sacrum | R/- | 12 | Zoledronic acid a (Embolisation) | Stable size No further recurrence |
| 18. F 22 | Distal Femur (multifocal) | RR/M | 12 | Zoledronic acid | Disease progression |
| 19. F 17 | Proximal tibia | R/M | 24 | Zoledronic acid (Interferon α, Cyclophosphamide, Ifosfamide) | Lung mets stable No further recurrence |
| 20. F 32 | Pelvis | R/M | 24 | Zoledronic acid (Radiation, Embolisation) | Stable size Lung mets stable |
| 21. F 64 | Proximal tibia | R/M | Zoledronic acid (Embolisation) | No further recurrence Lung mets stable | |
| 22. F 30 | Proximal humerus | -/- | 24 | Zoledronic acid | Pain decrease No further recurrence |
| 23. F 49 | Sacrum | R/M | 3 | Zoledronic acid (Embolisation) | Disease progression |
| 24. F 31 | Fibula | (ST)RR/M | 30 | Zoledronic acid a | Lung mets stable No further recurrence |
| 25. F 51 | Distal radius | RR/M | 8 | Zoledronic acid | Lung mets stable |
* No surgical treatment
a - intra-op zoledronic acid for treatment of recurrent tumour
ST - soft tissue recurrence
R - episode of recurrence
M - lung metastasis