Table 4.
Odds ratios (OR)* and 95% confidence intervals (CI) for lung cancer risk according to CYP1A1 genotype groups and stratification by histological types.
| *1/*1 | *1/*2a |
*1/2B *2B/*3 *1/*2C |
*1/*4 *4/*4 *2A/*4 |
|
|---|---|---|---|---|
| Controls, N (%) | 189 (71.9) | 44 (16.7) | 8 (3.0) | 22 (8.4) |
| All cases, N (%) | 68 (66.7) | 10 (9.8) | 13 (12.7) | 11 (10.8) |
| OR (CI) | 1.0 | 0.51 (0.3-1.2) | 4.51 (1.8-11.9) | 1.29 (0.6-2.9) |
| p | 0.18 | < 0.01 | 0.29 | |
| Squamous-cell, N (%) | 35 (71.4) | 5 (10.2) | 7 (14.3) | 2 (4.1) |
| OR (CI) | 1.0 | 0.51 (0.2-1.6) | 5.01 (1.6-14.3) | 0.49 (0.1-2.4) |
| p | 0.37 | < 0.01 | 0.40 | |
| Adenocarcinoma, N (%) | 10 (66.7) | 1 (6.7) | 2 (13.3) | 2 (13.3) |
| OR (CI) | 1.0 | 0.41 (0.04-2.91)) | 4.71 (0.8-27.3) | 1.62 (0.3-7.7) |
| p | 0.51 | 0.10 | 0.65 | |
| SCLC, N (%) | 9 (60) | - | 2 (13.3) | 4 (26.7) |
| OR (CI) | 1.0 | nc | 6.97 (1.2-81.3) | 8.33 (1.1-15.2) |
| p | nc | 0.04 | 0.04 | |
| LCLC, N (%) | 14 (60.9) | 4 (17.4) | 2 (8.7) | 3 (13) |
| OR (CI) | 1.0 | 1.01 (0.3-3.1) | 2.7 (0.5-14.6) | 1.68 (0.4-5.2) |
| p | 1 | 0.24 | 0.75 |
*ORs were adjusted for age, sex, and smoking (non/moderate/heavy), taking the CYP1A1*1/*1 genotype as reference. Genotype groups were generated as described in the Methods section.
SCLC: Small-cell lung carcinoma.
LCLC: Large-cell lung carcinoma.
nc: non-calculable.