Skip to main content
. Author manuscript; available in PMC: 2011 May 4.
Published in final edited form as: Adv Mater. 2010 May 4;22(17):1946–1953. doi: 10.1002/adma.200903908

Table 2.

Binding affinity versus ligand density. The Au NPs were functionalized with mixed thiols of 1-hexanethiol and PFPA–thiol 3.

Percentage of
PFPA–Thiol 3		 d-Mannose Density
[nmol mg−1 Au NPs]		 Surface
Coverage [%] [a] 		Kd [nM]
10% 2.0 ± 0.54 2.8 123 ± 16
30% 5.3 ± 0.83 7.4 21.4 ± 7.3
50% 11.2 ± 2.32 16 16.3 ± 5.4
70% 24.3 ± 2.78 34 14.4 ± 2.4
90% 35.2 ± 1.29 49 12.7 ± 4.0
95% 42.6 ± 3.81 59 9.4 ± 2.3
98% 50.3 ± 4.17 70 6.7 ± 1.4
100% 57.4 ± 3.21 80 5.3 ± 1.6
[a]

The surface coverage was defined as the percentage of ligands coupled versus the theoretical maximal number of ligands occupying the nanoparticle [61].