Fig. 6.

Models for the Michaelis complex of CrAT for the forward and reverse reactions. The acetyl-CoA and carnitine substrates for the forward reaction are shown in brown and green, respectively. The substrates for the reverse reaction are shown in gray. The conformation of acetylcarnitine is modeled from that of hexanoylcarnitine. The side chain of His343 is shown in red and gray for the forward and reverse reactions, respectively. The Ser554 side chain is shown in black. The thin lines indicate some of the interactions in the complexes. Produced with Ribbons (39).