Figure 2.

Total plasma ghrelin levels (left two panels) during the small (top) and large meals (bottom). Only large meals suppressed total ghrelin levels significantly in either obese or lean subjects (^†p<0.005), and mixed model analysis showed a significant effect of meal type on these levels (p<0.001). However, there were no significant effects of obesity or interactions between obesity and meal type (p=n.s.). Active (acylated) ghrelin levels (right two panels) were suppressed in the lean subjects after intake of either meal (p<0.01 for both meal types), while in the obese subjects, only the large meal suppressed these levels (p=n.s. for small, p<0.05 for large). Symbols are defined in Figure 1