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. 2010 Sep 16;5(9):e12760. doi: 10.1371/journal.pone.0012760

Figure 6. MY-24 protects AG129 mice against lethal TCRV infection despite lack of inhibition of viral replication.

Figure 6

Mice were treated i.p. once daily for 7 days with the indicated doses of MY-24 or ribavirin, starting 4 h prior to TCRV challenge. A) Survival data are based on 7, 10, 10, 10, and 20 animals per group for the high-dose MY-24, intermediate dose MY-24, low-dose MY-24, ribavirin, and placebo groups, respectively. An additional 4 to 5 mice per group were sacrificed on day 8 of infection for B) serum, C) liver, D) lung, and E) spleen virus titer determinations. **P<0.01, ***P<0.001 compared to saline placebo-treated animals.