Scheme 1.
A. Primary and tertiary structure of MCoTI and Kalata cyclotides isolated from Momordica cochinchinensis and Oldenlandia affinis, respectively [6, 20, 21]. B. Multiple sequence alignment of cyclotide MCoTI-I with other squash trypsin inhibitors. Multiple sequence alignment was performed using TCoffee (http://ca.expasy.org/cgi-bin/hub) and visualized using Jalview [31].