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. Author manuscript; available in PMC: 2011 Sep 15.
Published in final edited form as: Cancer Res. 2010 Aug 24;70(18):7148–7154. doi: 10.1158/0008-5472.CAN-10-1457

Figure 1.

Figure 1

Generation of Mdm4 transgenic mice. (A) The chicken β-actin promoter and intron with a cytomegalovirus (CMV) immediate-early (IE) enhancer drive expression of the Mdm4 cDNA upon deletion of EGFP which is flanked by loxP sites. An internal ribosomal entry site allows LacZ expression. A rabbit β-globin polyadenylation signal (poly A) was placed at the 3’ end. ALF and E4 mark the location of primers for genotyping. (B) A constitutive Mdm4 transgene driven by the chicken β-actin promoter and CMV IE enhancer was used to generate Mdm4Tg6 and Mdm4Tg15 lines.