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. Author manuscript; available in PMC: 2011 Sep 15.
Published in final edited form as: Cancer Res. 2010 Aug 24;70(18):7148–7154. doi: 10.1158/0008-5472.CAN-10-1457

Figure 4.

Figure 4

Acceleration of tumorigenesis in p53+/− mice by overexpression of Mdm4. (A) Kaplan-Meier survival curves for Mdm4Tg1, p53+/−, Mdm4Tg1 p53+/−, and p53−/− mice. (B) Western blots of Mdm4Tg1p53+/− tumor lysates using Mdm4 and vinculin antibodies. The first lane is a Mdm4−/− p53−/ − MEF control. (C) Southern blot analysis of Mdm4Tg1 p53+/− tumor DNA samples. The asterisk denotes sample with LOH. HS, Histiocytic sarcoma; OS, osterosarcoma; Ly, lymphoma; NF, Neurofibrosarcoma; SN, Sarcoma, not otherwise specified; AC, Mammary Adenocarcinoma; ψ, p53 pseudogene. p53 homozygous (+/+), heterozygous (+/−) and null (−/−) tail DNAs were used as controls for the southern blot.