Table 2.
Tumor Spectra in Mdm4 transgenic mice
| Tumor Types | Mdm4Tg1 (N=24) | p53+/− (N=44) | Mdm4Tg1 p53+/− (N=44) | Mdm4Tg15 (N=13) |
|---|---|---|---|---|
| Sarcoma | 9 (37%) | 30 (68%) | 28 (64%) | 4 (31%) |
| Hemangiosarcoma | 4 | 3 | 1 | 0 |
| Osteosarcoma | 11 | 15 | 18 | 0 |
| Sarcoma, NOS2 | 4 | 12 | 7 | 33 |
| Malignant peripheral Nerve sheath tumor | 0 | 0 | 1 | 1 |
| Neurofibrosarcoma | 1 | |||
| Carcinoma | 3 (13%) | 2 (5%) | 5 (11%) | 1 (7%) |
| Adenocarcinoma | 2 | 1 | 4 | 0 |
| Spindle Cell Carcinoma | 0 | 1 | 0 | 0 |
| Squamous Cell Carcinoma | 1 | 0 | 1 | 0 |
| Hepatocellular Carcinoma | 0 | 0 | 0 | 1 |
| Lymphoma | 8 (33%) | 10 (23%) | 5 (11%) | 4 (31%) |
| Histiocytic Sarcoma4 | 4 (17%)5 | 2 (5%) | 6 (14%) | 4 (31%)5 |
1
This Osteosarcoma had metastasis
2
Not Otherwise Specified
3
1 of 3 Sarcomas NOS had metastasis
4
Macrophage origin
5
2 of 4 Histiocytic Sarcomas had metastasis