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. 2010 Sep 22;99(6):1925–1931. doi: 10.1016/j.bpj.2010.07.019

Figure 4.

Figure 4

LASR applied to a model kinetic trap. (a) Donor-labeled RNA hairpin (HP1 or HP3) was surface-immobilized on the quartz slide in the presence of an acceptor-labeled complementary RNA hairpin (HP2 or HP4). The kissing complex forms and dissociates at room temperature, but extended duplex formation is slow. LASR causes a T-jump (ΔT) that induces extended duplex formation. (b–e) Characteristic single-molecule time trajectories of LASR-induced kissing complex dissociation, extended duplex formation, kissing complex formation, and extended duplex formation from free hairpins, respectively.