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. 2010 Sep 22;99(6):1773–1782. doi: 10.1016/j.bpj.2010.06.076

Figure 1.

Figure 1

(Top) CD spectra at 45°C of SP-B1-25 at a P/L molar ratio of 1:100, 1:33, and 1:20 averaged together in 4:1 DPPC/POPG (black solid line) and in 3:1 POPC/POPG (gray solid line). The CD lineshapes for the individual P/L molar ratios are identical. A spectrum of SP-B1-25 dissolved in MeOH is shown for comparison (dashed line). The final peptide concentration was ∼40 μM in all samples. (Bottom) DSC scans for 4:1 DPPC/POPG LUVs with SP-B1-25 at the indicated molar peptide percentages. The onset of phase separation is apparent at a P/L ratio of 1:200 and continues with increasing amounts of peptide.