Table 2.

White matter tracts demonstrating reduced volume in risk allele homozygotes compared to heterozygotes and major allele homozygotes. Two discrete clusters within the right occipital lobe, the right caudal inferior fronto-occipital fasciculus and right posterior thalamic radiation, are recorded by brain region separately. p < 0.05 family-wise error corrected. MNI coordinates in mm, cluster-level significance, cluster extent, voxel-level significance and Z-scores are reported.

Reduced white matter volume in TT compared to AT and AA (cluster-level threshold, p < 0.05 FWE-corrected)
Brain region	MNI coordinates (mm)			Cluster-level		Voxel-level
x	y	z	p(FWE-corrected)	Cluster extent	p(FWE-corrected)	Z-score
Right caudal inferior fronto-occipital fasciculus	31	− 73	− 4	2.17E−5	258	0.003	5.12
Right posterior thalamic radiation	27	− 84	5			0.01	4.89
Left posterior thalamic radiation	− 23	− 87	− 1	0.012	20	0.028	4.64
Right rostral cingulum	11	41	22	0.018	528	0.164	4.18