Table 1.
Case reports of interstitial pneumonitis associated with interferon therapy for hepatitis C virus
| Ref. | Yr | Age (yr)/sex | Administered | Duration of IFN therapy (wk) | Diagnostic method | Treatment | Outcome |
| [1] | 1993 | 60/F | IFNα-2b | 8 | C, R, B | D | Resolved |
| [2] | 1994 | 58/F | IFN-α | 12 | C, R, B | D | Resolved |
| 56/M | IFN-α | 6 | C, R, B | D + S | Resolved | ||
| 72/F | IFN-α | 3 | C, R | D + S | Improvement | ||
| [3] | 1994 | 48/F | IFN-α | 9 | C, R, B | D + S | Resolved |
| [4] | 1994 | 62/F | IFN-α | 3 | C, R, B | D + S | Resolved |
| [5] | 1996 | 49/F | IFNα-2b, Sho-saiko-to | 6 | C, R, B | D + S | Resolved |
| 59/M | IFNα-2b, Sho-saiko-to | 4 | C, R, B | D + S | Resolved | ||
| 42/M | IFNα-2b | 16 | C, R, B | D + S | Resolved | ||
| [6] | 1996 | 46/M | IFN-α, Sho-saiko-to | 4 | C, R | D | Resolved |
| 57/M | IFN-α | 5 | C, R | D | Resolved | ||
| 59/M | IFN-α | 23 | C, R | D | Resolved | ||
| [7] | 2001 | 57/M | IFN-α, ribavirin | 12 | C, R, B | D | Resolved |
| [8] | 2002 | 48/F | IFNα-2b, ribavirin | 24 | C, R | D | Resolved |
| PEGIFNα-2a, ribavirin | 6 | C, R, B | D + S | Improvement | |||
| 50/M | IFNα-2b, ribavirin | 4 | C, R, B | D + S | Resolved | ||
| [9] | 2003 | 49/M | PEGIFNα-2b, ribavirin | 2 | C, R, B | D + S | Death |
| [10] | 2004 | 71/F | PEGIFNα-2a, ribavirin | 20 | C, R, B | D | Resolved |
| [11] | 2004 | 51/M | PEGIFNα-2b, ribavirin | 5 | C, R, B | D + S | Death |
| [12] | 2005 | 58/F | PEGIFNα-2b, ribavirin | 12 | C, R, B | D + S | Resolved |
| PEGIFNα-2a, ribavirin | 12 | C, R | D | Resolved | |||
| [13] | 2006 | 68/F | IFNα-2b, ribavirin | 14 | C, R, B | D + S | Resolved |
| [14] | 2007 | 47/F | PEGIFNα-2b, ribavirin | 10 | C, R, B | D + S | Resolved |
| [15] | 2008 | 43/F | PEGIFNα-2b, ribavirin | 48 | C, R | D + S | Death |
| [16] | 2009 | 39/F | PEGIFNα-2a, ribavirin | 36 | C, R, B | D + S | Resolved |
| [17] | 2010 | 51/M | PEGIFNα-2b, ribavirin | 4 | C, R, B | D + S | Resolved |
B: Biopsy proven diagnosis; C: Clinical diagnosis; R: Radiological diagnosis; PEGIFN-α: Pegylated interferon α; D: Discontinuation IFN-α; S: Corticosteroids therapy.