Table 2.
Neuropsychological Test Differences Stratified by Subtype Using Analysis of gag and gp41 Genes
| Median score ± standard error, by HIV subtype |
||||
|---|---|---|---|---|
| Test | A (n = 33) | C (n = 2) | D (n = 9) | A/D recombinant (n = 16) |
| WHO UCLA AVLT trial 5 | 38.0 ± 1.2 | 39.5 ± 10.0 | 35.0 ± 1.8 | 36.5 ± 1.6 |
| Timed Gait | 9.0 ± 0.4 | 9.0 ± 0.4 | 9.7 ± 0.6 | 8.2 ± 0.3 |
| Grooved Pegboard Test | ||||
| Dominant hand | 85.0 ± 4.2 | 146.5 ± 79.5 | 98.0 ± 11.1 | 72.0 ± 5.4 |
| Nondominant hand | 102.0 ± 13.7 | 158.5 ± 77.5 | 121.0 ± 12.5 | 100.0 ± 6.3 |
| Symbol Digit Modalities Test | 23.0 ± 1.7 | 31.0 ± 4.0 | 20.0 ± 2.6 | 20.5 ± 2.2 |
| Color Trails Test | ||||
| Part 1 | 94.0 ± 11.0 | 75.5 ± 12.5 | 125.0 ± 12.8 | 88.0 ± 10.8 |
| Part 2 | 180.0 ± 16.4 | 270.5 ± 116.5 | 215.0 ± 24.7 | 174.0 ± 21.5 |
| Digit Span | ||||
| Forward | 6.0 ± 0.2 | 5.5 ± 0.5 | 5.0 ± 0.2a | 5.0 ± 0.2 |
| Backward | 3.0 ± 0.1 | 3.5 ± 0.5 | 3.0 ± 0.3 | 3.0 ± 0.2 |
| Finger tapping test | ||||
| Dominant hand | 165.0 ± 7.3 | 181.0 ± 21.0 | 163.0 ± 15.8 | 200.0 ± 12.0 |
| Nondominant hand | 172.0 ± 8.8 | NA | 192.5 ± 37.5 | 170.5 ± 10.0 |
| Category naming | 13.0 ± 0.8 | 15.0 ± 4.0 | 12.0 ± 1.1 | 13.0 ± 0.5 |
NOTE. NA, not available; WHO UCLA AVLT, World Health Organization–University of California-Los Angeles Auditory Verbal Learning test.
a
P = .04 for subtype D vs subtype A.