Table 3.

Top hits from published asthma GWAS and association to BMI and asthma in CAMP

Position	Nearby gene(s)	SNP	Original p-value	Population	Children included	Ref	Association in CAMP
							p-value BMI*	p-value asthma†
1q31	DENND1B/CRB1	rs2786098	9 × 10−11	Caucasian	Yes	26	0.14	0.96
2q12	IL1RL1/IL18R1	rs1420101	6 × 10−12	Caucasian, East Asian	Yes	21	0.81	0.23
2q12.3	DPP10	rs1435879	3 × 10−6	African ancestry	Yes	25	0.72	0.18
3p12	ROBO1/GBE1	rs275358	4 × 10−6	Caucasian	Yes	26	0.10	0.54
5q12	PDE4D	rs1588265	4 × 10−7	Caucasian	Yes	23	0.28	4 × 10−7
5q22	WDR36/TSLP	rs2416257	1 × 10−4	Caucasian, East Asian	Yes	21	0.27	0.82
5q33	ADRA1B	rs10515807	4 × 10−6	African ancestry	Yes	25	0.99	NA
6q23	MYB	rs9494145	4 × 10−3	Caucasian, East Asian	Yes	21	0.21	0.79
6q27	PDE10A	rs1358786‡	8 × 10−8	Caucasian	Yes	26	0.75	0.57
9q21.31	TLE4	rs2378383	7 × 10−7	Hispanic/Mexican	Yes	22	0.38	0.59
9p23	PTPRD	rs1326772	8 × 10−7	Caucasian	Yes	26	0.57	0.54
9q24	IL33	rs3939286	5 × 10−6	Caucasian, East Asian	Yes	21	0.07	0.26
17q21	ORMDL3/GSDML	rs7216389	9 × 10−11	Caucasian	Yes	24	0.81	0.002
20q12	PRNP	rs6052761	2 × 10−6	African ancestry	Yes	25	0.64	0.82

^*Linear regression in asthmatics using PLINK.

^†Case-control association using PLINK.

^‡Not genotyped in CAMP. Association to a proxy SNP, rs1033700 (r² = 0.86 with rs1358786) was reported.

NA = not available (excluded after QC).