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. Author manuscript; available in PMC: 2010 Sep 17.
Published in final edited form as: FEMS Microbiol Rev. 2009 Jan 19;33(3):488–503. doi: 10.1111/j.1574-6976.2008.00159.x

Table 3.

Virulence-related defects of Salmonella dam mutants

Stage of infection Virulence defect Tentative cause
Intestinal Bile sensitivity Envelope instability
MutHLS-induced DNA breakage
Deficient invasion of epithelial cells Reduced SPI-1 expression
Reduced colonization of the caecum Ectopic synthesis of Std fimbriae
Systemic Sensitivity to hydrogen peroxide MutHLS-induced DNA breakage
Reduced colonization of lymph nodes, liver and spleen Impaired expression of spv operon products
Reduced spleen colonization Ectopic synthesis of Std fimbriae