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Identification of isoform-selective peptides. a) Active substrates from the first peptide library (top) demonstrate enhanced selectivity after changing the residue in the Z position (bottom). b) An overlay of SAMDI spectra of substrates S5−S8 treated with KDAC2, KDAC8, SIRT1, and KDAC3/SMRT demonstrate the selectivity of each peptide substrate. Deacetylase activity is indicated by the red arrow.
