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Measurement of endogenous KDAC activity using SAMDI. a) Nuclear extracts (NE) from HeLa, Jurkat, and smooth muscle cells were applied to arrays presenting the selective substrates and analyzed by SAMDI. b) Treatment of HeLa nuclear extracts on the selective substrates in the absence of NAD+, the required cofactor for SIRT1 activity, causes a decrease in deacetylation of the SIRT1 substrate.
