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. 2010 Aug 30;107(37):16268–16273. doi: 10.1073/pnas.1002696107

Fig. 3.

Fig. 3.

miR-1 expression analysis in Zmpste24−/− mice and Hutchinson–Gilford progeria cells. (A) qPCR analysis of putative IGF-1 microRNAs. A selection of TargetScan-predicted microRNAs targeting IGF-1 (Left) were analyzed by qPCR in liver samples (Right) from WT (blue bars) and Zmpste24−/− mice (red bars). (B) miR-1 expression studies were extended to the indicated tissues from WT and Zmpste24−/− mice. (C) miR-1 expression levels in in human fibroblasts from patients with Hutchinson–Gilford progeria syndrome. (D) miR-1 expression levels in WT fibroblasts untreated and treated with 0.5 μM doxorubicin for 24 h.